Nitrocard

Aristopharma Ltd
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Nitrocard
Glyceryl Trinitrate (Nitroglycerin)
2.6 mg
Orion Pharma Ltd.

Indicated For:

Nitrocard – Nitroglycerin Tablet is indicated for the prophylaxis of chronic stable angina pectoris.

৳ 5.00

In stock

Indications
Nitrocard  Tablet is indicated for the prophylaxis of chronic stable angina pectoris.

Therapeutic Class
Nitrates: Coronary vasodilators

Pharmacology
Nitrocard – The principal pharmacological action of nitroglycerin is a relaxation of vascular smooth muscle and consequent dilatation of peripheral arteries and veins. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end-diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure (afterload). Dilatation of the coronary arteries also occurs.

Dosage & Administration
Tablet or Capsule-
Adults and Elderly Patients: Dosage should be adjusted to the requirements of the individual patient but will usually be 1 or 2 tablets taken three times daily. The lowest effective dose should be used.

Initial Dilution: Aseptically transfer the contents of one nitroglycerin ampoule (containing 50 mg of nitroglycerin) into a 500 ml glass bottle of either Dextrose (5%) Injection or Sodium Chloride Injection (0.9%). This yields a final concentration of 100mcg/ml.

Maintenance Dilution: It is important to consider the fluid requirements of the patient as well as the expected duration of infusion in selecting the appropriate dilution of Nitroglycerin Injection. After the initial dosage titration, the concentration of the solution may be increased, if necessary, to limit fluids given to the patient. The Nitrocard –  nitroglycerin concentration should not exceed 400 mcg/ml.

Interaction
Orthostatic hypotension may occur with the combined use of calcium channel blockers, antihypertensive agents, phenothiazine, and tricyclic antidepressants. Use of alcohol with nitroglycerin may produce severe hypotension and collapse. Oral nitroglycerin may enhance the bioavailability of dihydroergotamine.
Contraindications
Hypersensitivity to nitrates. Obstructive hypertrophic cardiomyopathy. Low cardiac output secondary to hypovolemia. Inferior myocardial infarction with right ventricular involvement. Raised intracranial pressure. Mitral valve propalpse. Glaucoma.

Side Effects
Nitrocard – Side-effects include facial flushing, headache, dizziness and postural hypotension which may be associated with reflex tachycardia or paradoxical bradycardia. Toxic effects of Nitroglycerin include vomiting, restlessness, cyanosis, methaemoglobinaemia and syncope.

Pregnancy & Lactation

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Nitroglycerin should be given to pregnant women only if clearly needed.

Nursing Mothers: It is not known whether nitroglycerin is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Nitroglycerin spray is administered to a nursing woman.

Precautions
Nitrocard –  Only the smallest dose required for effective control of the acute anginal attack should be used. Excessive use may lead to the development of tolerance. This drug should be used with caution in patients who may be volume-depleted or are already hypotensive.

Overdose Effects
Symptoms: Hypotension, reflex tachycardia, pallor, sweating, diarrhoea, weak pulse, collapse, syncope, dizziness, headache, asthenia, nausea, vomiting, methemoglobinaemia. Bradycardia, psychosis and resp depression may occur in severe poisoning.

Management: Increase central fluid volume through passive elevation of patient’s legs. IV infusion of normal saline or similar fluid may also be necessary. Methylene blue infusion may be given in case of methaemoglobinaemia. Administer oxygen if necessary.

Use in Special Population
Nitrocard – Use in neonates: Safety and efficacy for use in infants and children have not been established.
Use in children: Safety and efficacy for use in children has not been established.

Storage Conditions
Nitrocard –  Store between 15-30° C. Protect from light and moisture. Keep away from the reach of children.

 

If you need any assistance/consultation, please do not hesitate to contact us.

SKU: O-NIT-ARI-2.6 Category:
Weight 0.0026 g
Drug Manufacturer

Aristopharma Ltd

Form Of Drug

Tablet

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