Cinarzin Tablet

Ibn-Sina Pharmaceuticals Ltd.
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Cinarzin Tablet

Cinnarizine

15 mg

Indicated For:

It is mainly used for the symptomatic treatment of nausea and vertigo due to Meniere’s disease and other labyrinthine disturbances and for the prevention and treatment of motion sickness. It is also used in the management of various vascular disorders.

Cerebral circulatory disorders:

  • Prophylaxis and maintenance therapy for symptoms of cerebral vascular spasms and arteriosclerosis such as dizziness, ear buzzing (tinnitus), vascular headache, unsociability and irritability, fatigue, sleep rhythm disorders such as premature awakening, involutional depressions, loss of memory and lack of concentration, incontinence and other disorders due to aging.
  • Sequel of cerebral and cranial trauma.
  • Post-apoplectic disorders.
  • Migraine.

Peripheral circulatory disorders: Prophylaxis and maintenance therapy for symptoms of vascular spasms and arteriosclerosis (obliterating arteritis, thromboangitis obliterans, Raynaud’s disease, diabetes, acrocyanosis, perrio, etc.) such as: intermittent claudication, trophic disturbances, pregangrene, trophic and varicose ulcers, paraesthesia, nocturnal cramps, cold extremities.

Disorders of balance:

  • Prophylaxis and maintenance therapy for symptoms of labyrinthine arteriosclerosis, vestibular irritability, Meniere’s syndrome, such as vertigo, dizziness, giddiness, syncopal attacks, tinnitus, nystagmus, nausea and vomiting.
  • Prophylaxis of motion sickness.

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Indications for Cinarzin 

It is mainly used for the symptomatic treatment of nausea and vertigo due to Meniere’s disease and other labyrinthine disturbances and for the prevention and treatment of motion sickness. It is also used in the management of various vascular disorders.

Cerebral circulatory disorders:

  • Prophylaxis and maintenance therapy for symptoms of cerebral vascular spasms and arteriosclerosis such as dizziness, ear buzzing (tinnitus), vascular headache, unsociability and irritability, fatigue, sleep rhythm disorders such as premature awakening, involutional depressions, loss of memory and lack of concentration, incontinence and other disorders due to aging.
  • Sequel of cerebral and cranial trauma.
  • Post-apoplectic disorders.
  • Migraine.

Peripheral circulatory disorders: Prophylaxis and maintenance therapy for symptoms of vascular spasms and arteriosclerosis (obliterating arteritis, thromboangitis obliterans, Raynaud’s disease, diabetes, acrocyanosis, perrio, etc.) such as: intermittent claudication, trophic disturbances, pregangrene, trophic and varicose ulcers, paraesthesia, nocturnal cramps, cold extremities.

Disorders of balance:

  • Prophylaxis and maintenance therapy for symptoms of labyrinthine arteriosclerosis, vestibular irritability, Meniere’s syndrome, such as vertigo, dizziness, giddiness, syncopal attacks, tinnitus, nystagmus, nausea and vomiting.
  • Prophylaxis of motion sickness.

Therapeutic Class
Anti vertigo drugs

Description
Cinarzin – Cinnarizine provides quick relief of various symptoms of cerebral and peripheral circulation disorders. Cinnarizine protects attacks of vascular headache such as migraine. Cinnarizine normalizes cerebral circulation time and improves cerebral irrigation in patients suffering from the disorders of cerebral circulation. Cinnarizine normalizes arterial pulsations in patients suffering from vasospastic disorders. Cinnarizine significantly increases the rate of inflow or pulsation and the blood flow in the most affected limb as well as the walking distance of patients suffering from intermittent claudication.

Pharmacology
Cinarzin – Cinnarizine acts as an antihistamine, labyrinthine sedative and a peripheral antivasoconstrictor. Inarzin is a selective calcium antagonist, inhibiting the influx of Ca2+ intracellularly. It prevents the Ca2+ dependent contraction of arterial smooth muscle by inhibiting Ca2+ influx through smooth muscle calcium channels and thereby, improves vestibular symptoms and prevents peripheral arterial disease

Dosage & Administration
Peripheral vascular disease:
Adult: 75 mg bid or tid.
Cerebrovascular disorders:
Adult: 75 mg once daily.
Motion sickness:
Adult: 30 mg 2 hr before travel then 15 mg 8 hrly during the journey if necessary.
Child: 5-12 yr 15 mg 2 hr before travel then 7.5 mg 8 hrly during the journey as necessary.
Vertigo and vestibular disorders:
Adult: 30 mg tid or 75 mg 1-2 times daily.
Child: 5-12 yr 15 mg tid.

Interaction
Concurrent use of alcohol, CNS depressants or tricyclic antidepressants may potentiate the sedative effects of either these drugs or of Cinnarizine. Therefore, it is advisable to avoid these drugs while taking Cinnarizine.

Contraindications
Contraindicated in Known hypersensitivity to Cinnarizine, Parkinson’s disease, Hypotension

Side Effects
Side effects such as somnolence and gastrointestinal disturbances are extremely rare. They are transient and may be readily prevented by achieving the optimal dosage gradually. Combination therapy with other drugs is possible. Whenever indicated, caution should be taken in hypotension (high doses). Rarely, extrapyramidal symptoms in elderly on prolonged therapy.

Pregnancy & Lactation
Pregnancy Category C. The safety of Cinarzin – Cinnarizine in human pregnancy has not been established. Therefore, it is not advisable to administer Cinnarizine in pregnancy.

Lactation: It is not known if Cinnarizine is excreted in human breast milk. Use of Cinnarizine during breast feeding is not advised.

Precautions
Patient with hypotension (high dose), Parkinson’s disease, porphyria. Renal and hepatic impairment. Childn. Pregnancy and lactation.

Overdose Effects
Symptoms: Consciousness alterations ranging from somnolence to stupor and coma, vomiting, extrapyramidal symptoms, hypotonia; seizures may occur in young children.

Management: Symptomatic and supportive treatment. May consider admin of activated charcoal within 1 hr of ingestion.

Use in Special Population
Neonates: Cinnarizine is not indicated in neonates.

If you need any assistance/consultation, please do not hesitate to contact us.

SKU: O-CIN-IBN-15 Category:
Weight 0.015 g
Drug Manufacturer

Form Of Drug

Tablet

Generic Names

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